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Variation In Recovery: Role of Gender on Outcomes of Young AMI Patients

Virgo Study Partnerships


Dr. Hector Bueno
"IM-JOVEN provides an unprecedented opportunity to allow comparisons between cultures and health care systems"
- Dr. Héctor Bueno

Infarto de miocardio en la Mujer Joven (IM-JOVEN), a study in Spain that is parallel to VIRGO, presents an unprecedented opportunity to learn about the presentation, clinical management, and outcomes for young patients with acute myocardial infarctions (AMI) internationally.

In Spain, more than 55,000 patients are hospitalized with an AMI annually, of whom approximately 2.5% are women younger than 55 years. Despite the lower incidence of AMI among young women (<55 years) in Spain, their mortality rate appears greater than similarly aged men.

IM-JOVEN has adopted all VIRGO policies and protocols to ensure complete alignment and data quality across all sites, and will facilitate ancillary studies using data collected both in the United States and Spain. Through this partnership, IM-JOVEN hopes to recruit 300 women and 150 men between 18 and 55 years hospitalized with an AMI in Spain.

IM-JOVEN is principally funded by Spanish sources (Centro Nacional de Investigación Cardiovascular (CNIC), Fondo de Investigaciones Sanitarias del instituto Carlos III, and Sociedad Española de Cardiología), and is supported by CNIC, the Working Group on Ischemic Heart Disease & Coronary Care Units of the Spanish Society of Cardiology, and the Instituto Carlos III-related national cardiovascular research networks RECAVA (Red de Investigación Cardiovascular), and HERACLES (Hipertensión Esencial: Red de Análisis de Canales iónicos de la musculatura Lisa arterial y su Explotación terapéutica Sistemática). CNIC is led by Valentin Fuster, MD and has tasked Anagram-ESIC, a clinical research organization, with administering the study in Spain.

Recent Progress Report

For more information regarding IM-JOVEN, please contact:

Héctor Bueno, MD PhD
Servicio de Cardiología
Hospital General Universitario Gregorio Marañón,
Doctor Esquerdo 46, 28007, Madrid, Spain


VIRGO-Australia is an independent project working in close collaboration with the parent VIRGO study, adopting the same study design and instruments. Through this partnership, VIRGO-Australia hopes to recruit 70 women and 150 men between 18 and 55 years hospitalized with an AMI from three of the main teaching hospitals in South Australia: The Queen Elizabeth, the Lyell McEwin and the Royal Adelaide Hospital. VIRGO-Australia enrolled their first patient in 2009 and despite remaining unfunded has flourished due in part to the support and enthusiasm of site coordinators, Rachel Dreyer and Yang Timothy Du who also work in close alliance with resident Australian VIRGO Coordinator - Gabrielle Douglas.

Dr. John Beltrame
"With 70% of Australian women unaware of their risk of heart disease, our goal is to establish a collaborative team here in South Australia focused on coronary heart disease in young women."
- Dr. John Beltrame

Heart disease tragically claims the lives of 30 Australian women every day. Despite its increased prevalence, most Australians are not aware that heart disease kills more women than any other disease. It is one of the leading causes of death in women aged 55 and younger, accounting for more than 8,000 deaths annually. VIRGO-Australia hopes to identify possible causes for the poorer outcome in young women with AMI.

With a strong research interest in coronary artery spasm and microvascular dysfunction, Dr. John Beltrame’s research has defined racial differences in vasomotor reactivity (between Japanese and Caucasians), identified a new coronary microvascular disorder – the coronary slow flow phenomenon, and more recently characterized the frequency of angina amongst Australian stable angina patients. The Australian investigators bring expertise in coronary plaque biology, microvascular dysfunction and coronary heart disease outcomes.

Progress Report

For more information regarding VIRGO-Australia please contact:

Michell Professor of Medicine, The University of Adelaide
The Queen Elizabeth Hospital Campus
Woodville, South Australia 5011

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